Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hlp
Q-score: 0.435
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hma
Q-score: 0.424
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman (620 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Beta-d-mannopyranose (180 Da, Ligand)
- Cav1.2alpha2delta1beta2b (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hmb
Q-score: 0.472
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (3r)-1-benzylpiperidin-3-yl methyl (2r,3r,4r,5r,6s)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate (506 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
human glycine transporter 1 in complex with glycine in occluded conformation
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8wfi
Q-score: 0.644
Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y
Cell (2024) 187 pp. 1719- [ DOI: doi:10.1016/j.cell.2024.02.026 Pubmed: 38513663 ]
- Glycine (75 Da, Ligand)
- Human glycine transporter 1 (glyt1) (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Isoform glyt-1b of sodium- and chloride-dependent glycine transporter 1 (63 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
human glycine transporter 1 in complex with ALX-5407 in inward facing conformation
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8wfj
Q-score: 0.479
Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y
Cell (2024) 187 pp. 1719- [ DOI: doi:10.1016/j.cell.2024.02.026 Pubmed: 38513663 ]
- Alx5407 (393 Da, Ligand)
- Human glycine transporter 1 (Complex from Homo sapiens)
- Sodium- and chloride-dependent glycine transporter 1 (72 kDa, Protein from Homo sapiens)
human glycine transporter 1 in complex with SSR504734 in outward facing conformation
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8wfk
Q-score: 0.542
Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y
Cell (2024) 187 pp. 1719- [ DOI: doi:10.1016/j.cell.2024.02.026 Pubmed: 38513663 ]
- Chloride ion (35 Da, Ligand)
- Human glycine transporter 1 (Complex from Homo sapiens)
- Ssr504734 (396 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium- and chloride-dependent glycine transporter 1 (72 kDa, Protein from Homo sapiens)
human glycine transporter 1 in complex with PF-03463275 in outward facing conformation
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8wfl
Q-score: 0.47
Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y
Cell (2024) 187 pp. 1719- [ DOI: doi:10.1016/j.cell.2024.02.026 Pubmed: 38513663 ]
- Pf-3463275 (376 Da, Ligand)
- Human glycine transporter 1 (Complex from Homo sapiens)
- Sodium- and chloride-dependent glycine transporter 1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with white-tailed deer ACE2
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8hfx
Q-score: 0.46
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ Pubmed: 37676003 DOI: doi:10.1128/jvi.00505-23 ]
- Angiotensin-converting enzyme (71 kDa, Protein from Odocoileus virginianus texanus)
- Sars-cov-2 omicron ba.1 spike protein, envelope glycoprotein chimera in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein,envelope glycoprotein (139 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Omicron BA.1 spike protein receptor-binding domain in complex with white-tailed deer ACE2
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8hfy
Q-score: 0.506
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ Pubmed: 37676003 DOI: doi:10.1128/jvi.00505-23 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 omicron ba.1 spike protein receptor-binding domain in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme (69 kDa, Protein from Odocoileus virginianus texanus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with white-tailed deer ACE2
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8hfz
Q-score: 0.423
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ Pubmed: 37676003 DOI: doi:10.1128/jvi.00505-23 ]
- Angiotensin-converting enzyme (76 kDa, Protein from Odocoileus virginianus texanus)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 prototype spike protein in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (135 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)